Manchester United and Liverpool are two of England's most successful clubs after being crowned league champions 39 times between them.
But when the fierce rivals meet at Old Trafford on Monday evening, both will be searching for a first win after underwhelming starts to the season.
Liverpool have yet to lead after drawing their opening two games against Fulham and Crystal Palace, while Jurgen Klopp has had to contend with injuries and a red card for new £64m signing Darwin Nunez.
United have lost their opening two matches under Erik ten Hag, including a humiliating 4-0 defeat at Brentford.
Having lost their last two matches of 2021-22 under interim manager Ralf Rangnick, United are looking to avoid a fifth straight league defeat for the first time since a run of seven between January and March 1972.
With disgruntled United fans planning a fresh protest against the "failing ownership" of the Glazers before kick-off, it promises to be a lively night both on and off the pitch.
Will Liverpool kick-start season at Old Trafford?
If Liverpool's recent Premier League form over United is anything to go by, this game has come around at just about the right time for Klopp's side as they look to kick-start their season.
The Reds are unbeaten in their past eight top-flight matches against United, taking 18 points from 24.
Indeed, since United last defeated their rivals in the league in March 2018, they have sacked two managers [Jose Mourinho and Ole Gunnar Solskjaer], appointed one caretaker [Michael Carrick], appointed one interim [Ralf Rangnick] and appointed another permanent manager [Ten Hag].
Liverpool have scored 13 goals in the past three meetings, nine without reply in last season's two games.
When Klopp's side demolished United 5-0 in the corresponding fixture last season, Solskjaer lasted four more matches before he was fired.
Egypt forward Mohamed Salah has scored six goals in his last three matches against United.
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